|
KMID : 1128320090070010020
|
|
Electrolytes & Blood Pressure
2009 Volume.7 No. 1 p.20 ~ p.24
|
|
|
Role of Pendrin in Acid-base Balance
|
|
Chang Jae-Hyun
Kim Se-Joong
|
|
|
Abstract
|
|
|
|
Pendrin (SLC26A4) is a Na＋-independent Cl－/HCO3－ exchanger which is expressed in the apical membranes of type B and non-A, non-B intercalated cells within the distal convoluted tubule, the connecting tubule, and the cortical collecting duct. In those segments it mediates HCO3－ secretion and chloride (Cl－) absorption. In mice, no renal abnormalities are observed under basal conditions, and individuals with genetic disruption of the pendrin (SLC26A4) gene (Pendred syndrome) have normal acid-base balance. In contrast, there are definite differences under conditions wherein the transporter is stimulated. In animal studies, pendrin (SLC26A4) is upregulated with aldosterone analogues, Cl－ restriction, and metabolic alkalosis, and is down-regulated with Cl loading and metabolic acidosis, independently. However, the exact role of pendrin in humans has not been
|
|
|
KEYWORD
|
|
|
pendrin, SLC26A4, acidosis, renal tubular, metabolic alkalosis
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|
|